Expressly Unfit for the Laboratory
A new Berkeley Lab study challenges the orthodoxy of microbiology, which holds that in response to environmental changes, bacterial genes will boost production of needed proteins and decrease...
View ArticleMicrobial Who-Done-It For Biofuels
A multi-institutional collaboration led by researchers with the Joint BioEnergy Institute (JBEI) and Joint Genome Institute (JGI) has developed a promising technique for identifying microbial enzymes...
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Puzzling Question in Bacterial Immune System Answered
Short DNA sequences known as “PAM” (shown in yellow) enable the bacterial enzyme Cas9 to identify and degrade foreign DNA, as well as induce site-specific genetic changes in animal and plant cells. The...
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New Insight into an Emerging Genome-Editing Tool
The crystal structure of SpyCas9 features a nuclease domain lobe (red) and an alpha-helical lobe (gray) each with a nucleic acid binding cleft that becomes functionalized when Cas9 binds to guide RNA....
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Vast Gene-Expression Map Yields Neurological and Environmental Stress Insights
The remarkable complexity of the fruit fly transcriptome comes to life in this fruit fly embryo. Blue dye indicates the presence of RNA molecules in the brain from a previously uncharacterized gene...
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New Technique for Identifying Gene-Enhancers
With the new SIF-seq technique, mouse embryonic stem cells can be used to identify human embryonic stem cell enhancers even when the human enhancers are not present in the mouse genome. An...
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Encyclopedia of How Genomes Function Gets Much Bigger
A big step in understanding the mysteries of the human genome was unveiled today in the form of three analyses that provide the most detailed comparison yet of how the genomes of the fruit fly,...
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MaxBin: Automated Sorting Through Metagenomes
MaxBin, an automated software program for binning the genomes of individual microbial species from metagenomic sequences, is available on-line through JBEI. Microbes – the single-celled organisms that...
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RCas9: A Programmable RNA Editing Tool
A powerful scientific tool for editing the DNA instructions in a genome can now also be applied to RNA, the molecule that translates DNA’s genetic instructions into the production of proteins. A team...
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Golden Approach to High-speed DNA Reading
Schematic drawing of graphene nanopore with self-integrated optical antenna (gold) that enhances the optical readout signal (red) of DNA as it passes through a graphene nanopore. High-speed reading of...
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